Single-Course English 5 ECTS

Introduction to Medicinal Chemistry

Overall Course Objectives

To give an understanding of central topics and challenges in medicinal chemistry.

Learning Objectives

  • Demostrate familiarity with the drug development process
  • Know the types of biological targets (proteins, nucleic acids, carbohydrates and lipids) and the demands for drugs interacting with them
  • Understand the importance of screening and the difference between in vitro and in vivo assays, and demonstrate knowledge of biochemical assays and biophysical methods
  • Apply the principles for interactions between small molecules and biological macromolecules to predict binding interactions
  • Describe different analytical approaches to study and quantify binding interactions
  • Suggest structures of inhibitors, agonists and antagonists based on knowledge about natural substrates or ligands
  • Involve knowledge about pharmacokinetics in discussions of drug design
  • Apply SAR in evaluating leads
  • Demonstrate knowledge of the principles behind QSAR
  • Predict metabolites from the structure of drugs

Course Content

The course will give an introduction to the following:
Medicinal chemistry.
Drug targets.
Drug design.
Quantitative Structure-Activity Relationships (QSAR).
The need for pharmaceutical development.

Relevant drug types will be used to exemplify the subjects.

Recommended prerequisites

27002/27008/27020/26411/26202/26211/26222/26220, Bioscience and Organic Chemistry 2. Physical Chemistry for the Biological Sciences or Physical Chemistry 2 is also suggested.

Teaching Method

Lectures and problem solving.


See course in the course database.





13 weeks




DTU Lyngby Campus

Course code 26426
Course type Bachelor
Semester start Week 5
Semester end Week 19
Days Thurs 8-12

7.500,00 DKK