Biomolecular Chemistry

• Name Nature’s building blocks and their derivatives
• Account for the three dimensional structure of peptides and proteins
• Account for the importance of preparing different classes of biomolecules
• Choose appropriate protection groups for monosaccharides and amino acids in relation to their use in synthesis
• Design syntheses of lipids including appropriate methods and protection groups
• Design syntheses of oligosaccharides
• Design syntheses of peptides
• Design solid phase syntheses of oligonucleotides
• Draw reaction mechanisms for relevant reactions

Structure, function and nomenclature of the primary metabolites. Selective reactions with the functional groups in these molecules. Protecting groups and their applications in biomolecule synthesis. Coupling reactions including (automated) techniques by which nucleotides, monosaccharides and amino acids can be converted into oligonucleotides, oligosaccharides and peptides, respectively. Chemical properties of these products and their importance to biology and biological research.
Reaction mechanisms for the reactions in the curriculum.

26411/27002/27020, Organic Chemistry 2. Bioscience.

Lectures, problem solving and individual project (written assignment).