Single-Course English 5 ECTS

Discovery and design of biotherapeutics

Overall Course Objectives

This course introduces how biologics (biotherapeutic molecules) are discovered and designed, focusing on understanding disease mechanisms, druggable targets, drug discovery strategies, and the properties of key biological molecules that can be used for drug discovery purposes. Among the types of biotherapeutics that will be in focus are monoclonal antibodies, nanobodies, toxin-derived drugs, replacement therapies, mRNAs/DNAs, aptamers, carbohydrates, and cell-based therapeutics.

Learning Objectives

  • Explain what key properties for different biological molecules that may be relevant in different therapeutic situations
  • Analyze the key features of a disease (key disease mechanisms) and suggest (generic) relevant drug targets
  • Suggest relevant therapeutic scaffolds that could be useful for treating a given disease
  • Design general drug discovery strategies for the development of key therapeutic scaffolds (e.g. antibodies)
  • Understand the challenges of current therapeutics and propose alternative biotherapeutics that can overcome such challenges
  • Conceptualize improvements in current marketed biotherapeutics
  • Apply different computational tools for drug discovery
  • Analyze and explain where and what machine learning approaches are relevant in drug discovery

Course Content

Through lectures, exercises and group work, the course will cover basic theory, terminology, and analytical approaches within the topics of disease mechanisms and drug classes, replacement therapies and biobetters, convalescent plasma, human and non-human monoclonal antibodies, antibody engineering and advanced formats, nanobodies and alternative binding proteins, information-based therapeutics, toxin-derived therapeutics, microbiome therapeutics, gene and cell therapy, and computational methods in drug discovery. Moreover, the course will highlight current therapeutic challenges and involve students in case work around discovery and design of biologics.

Recommended prerequisites

Teaching Method

Lectures, exercises, and group work


Limited number of seats

Minimum: 20, Maximum: 120.

Please be aware that this course has a minimum requirement for the number of participants needed, in order for it to be held. If these requirements are not met, then the course will not be held. Furthermore, there is a limited number of seats available. If there are too many applicants, a pool will be created for the remainder of the qualified applicants, and they will be selected at random. You will be informed 8 days before the start of the course, whether you have been allocated a spot.

See course in the course database.





3 weeks




DTU Lyngby Campus

Course code 27075
Course type Bachelor
Semester start Week 23
Semester end Week 26
Days Mon-fri 8:00-17:00

7.500,00 DKK

Please note that this course has participants limitation. Read more