Single-Course English 5 ECTS

Development and production of vaccines

Overall Course Objectives

The course will deal with the challenges connected with the design, development, production and registration of vaccines based on knowledge of the immune system in human and animals. Therapeutic antibodies will also be taught. The students will acquire knowledge on vaccines for the treatment or prevention of infections, allergies, cancer and chronic inflammatory diseases. The students will understand the capacities and complexities of using the vaccinated host’s own immune system as both the target and the final executor of the desired effects of the drug. This biopharma approach to viewing vaccines as drugs is beneficial for understanding their discovery and production and also their use for preventive, therapeutic and post-exposure applications.

Learning Objectives

  • describe the basic nature of different vaccine types (live, inactivated, killed, subunit etc.)
  • explain the different methods available for antigen discovery and production
  • explain the method of action for adjuvants
  • design the construct of a vaccine with selection of antigen, adjuvant and delivery
  • design vaccine characteristics for a given application in practice, including the interplay with diagnostic assays
  • describe general principles for toxicology and hazard identification
  • explain the safety and efficacy aspects of vaccines and how these are tested
  • explain how to use, empower and produce immunoglobulins as one class of biopharmaceuticals
  • describe the principle governing preclinical and clinical testing of vaccines
  • design vaccines against allergy
  • design vaccines against cancer
  • apply the knowledge obtained in the course to describe the development of a new vaccine or therapeutic antibody against a selected topic

Course Content

This course will teach basic vaccinology such as different types of vaccine, administration of vaccines, and the immunology behind vaccine and adjuvant effects and explain some of the practical considerations behind using vaccines in humans and animals. Fundamental concepts in toxicology and hazard identification will be taught. Special considerations in vaccination against infections, cancer, or in the treatment of allergy will also be taught.

As an example of drug development and production, the process of developing and producing vaccines will be taught, from the definition of an antigen with the optimal characteristics of ease of production, stability and immunological relevance through the selection and/or development of adjuvants and testing in animals, to the final production and formulation of a vaccine for a specific use. This also includes requirements from authorities in the approval of a vaccine production and preclinical and clinical testing of vaccines. Finally, design and production of therapeutic antibodies will be taught.

Recommended prerequisites

27322/27070, The teaching will only briefly cover the cellular and humoral elements of the immune system and how the immune system reacts to infection. Thus it is a prerequisite that the student is already familiar with these elements of basic immunology or achieves this knowledge in parallel e.g. by taking the course in immunology (27070).

Teaching Method

The course is conducted as a combination of lectures and group work. An excursion to SSI will be planned. Relevant guest lecturers will attend selected topics.

Faculty

See course in the course database.

Registration

Language

English

Duration

13 weeks

Institute

Health Tech

Place

DTU Lyngby Campus

Course code 22230
Course type Candidate
Semester start Week 5
Semester end Week 19
Days Tues 13-17
Price

7.500,00 DKK

Registration