Single-Course English 10 ECTS

Organic Chemistry 4

Overall Course Objectives

To give the participants a theoretical and practical overview of organic chemical syntesis. To provide an introduction to physical organic chemistry and to deepen the understanding of reaction mechanisms and how to elucidate them. To engage the participants in a discussion of advanced problems in organic synthesis, and to make them familiar with modern synthetic strategy and methodology, including synthesis of compounds of interest to the pharmaceutical industry. To provide an overview of modern organometallic chemistry and catalysis.

Learning Objectives

  • Perform conformational analysis of cyclic and acyclic organic compounds
  • Give a detailed description of addition reactions of electrophilic alkenes
  • Demonstrate knowledge of diastereoselectivity in reactions of cyclic and acyclic substrates
  • Demonstrate knowledge of stereoelectronic effects in fragmentations and rearrangements
  • Propose methods to study organic chemical reactions
  • Use heterocyclic chemistry in synthetic planning
  • Demonstrate knowledge of the principles of asymmetric synthesis
  • Use reactions catalysed by transition metals
  • Plan organic syntheses based on the use of heteroatom reagents
  • Perform retrosynthetic analysis of complex organic molecules

Course Content

Molecular structure and MO-theory: repetition and extension of concepts. Hard/soft acids and bases. Pericyclic reactions (Diels-Alder, sigmatropic rearrangements etc.). Reaction mechanism and physical organic chemistry. Retrosynthetic analysis. Heteroatom reagents (P, Si, S, Se, B). Heterocyclic chemistry. Organometallic chemistry and catalysis. Asymmetric synthesis. Total synthesis.

Recommended prerequisites

26433, Organic Chemistry 3.

Teaching Method

Lectures and problem solving.



“Organic Chemistry” Second Edition (Clayden, Greeves, Warren; Oxford University Press, 2012

See course in the course database.





13 weeks




DTU Lyngby Campus

Course code 26444
Course type Candidate
Semester start Week 5
Semester end Week 19
Days Tues 13-17, Fri 8-12

15.000,00 DKK