Organic Chemistry 4

• Perform conformational analysis of cyclic and acyclic organic compounds
• Give a detailed description of addition reactions of electrophilic alkenes
• Demonstrate knowledge of diastereoselectivity in reactions of cyclic and acyclic substrates
• Demonstrate knowledge of stereoelectronic effects in fragmentations and rearrangements
• Propose methods to study organic chemical reactions
• Use heterocyclic chemistry in synthetic planning
• Demonstrate knowledge of the principles of asymmetric synthesis
• Use reactions catalysed by transition metals
• Plan organic syntheses based on the use of heteroatom reagents
• Perform retrosynthetic analysis of complex organic molecules

Molecular structure and MO-theory: repetition and extension of concepts. Hard/soft acids and bases. Pericyclic reactions (Diels-Alder, sigmatropic rearrangements etc.). Reaction mechanism and physical organic chemistry. Retrosynthetic analysis. Heteroatom reagents (P, Si, S, Se, B). Heterocyclic chemistry. Organometallic chemistry and catalysis. Asymmetric synthesis. Total synthesis.

26433, Organic Chemistry 3.

Lectures and problem solving.

Textbook:

“Organic Chemistry” Second Edition (Clayden, Greeves, Warren; Oxford University Press, 2012