Single-Course English 5 ECTS

Organic Chemistry 3

Overall Course Objectives

To broaden the participants’ knowledge of synthetic organic chemistry and to discuss reaction mechanisms in terms of molecular orbital theory. To make the participants familiar with modern synthetic strategy and methodology, including synthesis of compounds of interest to the pharmaceutical and fine chemicals industry.

Learning Objectives

  • Demonstrate knowledge of Molecular Orbital Theory (MO Theory)
  • Describe chemical reactions in terms of MO Theory
  • Use of the “hard/soft” theory of acids/bases (electrophiles/nucleophiles)
  • Demonstrate knowledge of the reactivity of carbonyl compounds
  • Use organometallic reagents (particularly Li, Mg and Cu reagents) in synthetic planning
  • Demonstrate knowledge of the role of stereoelectronic effects in elimination reactions
  • Use olefination reactions in synthetic planning
  • Describe in detail addition reactions to alkenes/alkynes
  • Demonstrate knowledge of pericyclic reactions, particularly the Diels-Alder reaction
  • Use enolates/enolate equivalents in synthetic planning
  • Plan organic syntheses based on the use of heteroatom reagents
  • Perform retrosynthetic analysis of organic compounds

Course Content

Introduction to molecular structure and molecular orbital theory, as a general tool for the understanding of chemical reactions. Stereochemistry. Methods for formation of carbon-carbon bonds. Reactions of carbonyl compounds (carbanion/enolate chemistry, Michael addition). Addition, elimination, and substitution reactions. Introduction to retrosynthetic analysis and synthetic planning.

Recommended prerequisites

26411, Organic Chemistry 2

Teaching Method

Lectures, examples and problem solving.



Text book:

“Organic Chemistry” Second Edition (Clayden, Greeves, Warren; Oxford University Press, 2012)

See course in the course database.





13 weeks




DTU Lyngby Campus

Course code 26433
Course type Candidate
Semester start Week 35
Semester end Week 48
Days Tues 13-17

7.500,00 DKK