Organic Chemistry 3

• Demonstrate knowledge of Molecular Orbital Theory (MO Theory)
• Describe chemical reactions in terms of MO Theory
• Use of the “hard/soft” theory of acids/bases (electrophiles/nucleophiles)
• Demonstrate knowledge of the reactivity of carbonyl compounds
• Use organometallic reagents (particularly Li, Mg and Cu reagents) in synthetic planning
• Demonstrate knowledge of the role of stereoelectronic effects in elimination reactions
• Use olefination reactions in synthetic planning
• Describe in detail addition reactions to alkenes/alkynes
• Demonstrate knowledge of pericyclic reactions, particularly the Diels-Alder reaction
• Use enolates/enolate equivalents in synthetic planning
• Plan organic syntheses based on the use of heteroatom reagents
• Perform retrosynthetic analysis of organic compounds

Introduction to molecular structure and molecular orbital theory, as a general tool for the understanding of chemical reactions. Stereochemistry. Methods for formation of carbon-carbon bonds. Reactions of carbonyl compounds (carbanion/enolate chemistry, Michael addition). Addition, elimination, and substitution reactions. Introduction to retrosynthetic analysis and synthetic planning.

26411, Organic Chemistry 2

Lectures, examples and problem solving.

Text book:

“Organic Chemistry” Second Edition (Clayden, Greeves, Warren; Oxford University Press, 2012)