Industrial BioReaction Engineering

• Describe the role of fermentation, microbial biocatalysis and enzymatic biocatalysis in the context of bioprocesses for production of industrial products (including cells, proteins and chemicals).
• Calculate mass balances for fermentations, including gas-liquid mass transfer
• Calculate elemental and redox balances for fermentation processes
• Evaluate the feasibility of fermentation, microbial biocatalytic and enzymatic processes in an industrial context and devise a research/development plan
• Analyze the consistency of experimental data using simple models
• Evaluate productivity requirements of large-scale fermentation and biocatalysis
• Calculate the heat of production of aerobic fermentation process
• Describe the principles for design and scale-up of a fermenter
• Describe the role of two-stage fermentation and in-situ product removal in the context of fermentations for production of industrial products
• Evaluate simple downstream concepts from fermentation processes
• Evaluate simple economic models of fermentation and biocatalytic processes.

Role of fermentation and biocatalysis in the sustainable manufacture of industrial products (including cells, proteins and chemicals). Stoichiometry of cellular reactions, redox balances, yield coefficients and black box models. Evaluation of the feasibility of fermentation, microbial biocatalysis, enzymatic biocatalysis, two-stage fermentation, and in-situ product removal in an industrial context. Heat balances. ATP balances and energetics. Scale-up and design of fermentation and biocatalytic processes. Integration of protein engineering, metabolic engineering and process engineering for design. Gas-liquid mass transfer for gaseous and aerobic fermentation and oxidative biocatalysis. Bioprocess economics.

27002/27022/27932, Kemi- , miljø- or Bioteknologifagpakke or bachelor or equivalent

Lectures and exercises

Parallel course to 28745