Single-Course Engelsk 5 ECTS

Implementation of industrial cell-based bioprocesses

Overall Course Objectives

The implementation of industrial bioprocesses is of increasing importance, and yet is frequently a bottleneck for commercialization of biotechnology. In this course, using a quantitative approach, bioprocesses are analyzed with respect to feasibility and scale-up for the production of a range of products (including cells, enzymes, proteins and chemicals). A variety of feedstocks (including waste sugars and gasses) as well as production technologies (including two-stage fermentation and microbial biocatalysis) will be discussed. Emphasis will be placed on bioprocess economics and process development.

See course description in Danish

Describe the role of fermentation and microbial biocatalysis in the context of bioprocesses for production of industrial products (including cells, enzymes, proteins and chemicals).
Calculate mass balances, gas-liquid mass transfer, heat transfer, elemental and redox balances as a tool to assess process feasibility.
Evaluate productivity requirements of large-scale fermentation and microbial biocatalysis.
Describe the principles for design and scale-up of a bioreactor.
Evaluate alternative feedstocks for bioprocesses.
Describe the role of two-stage fermentation and in-situ product removal in the context of fermentations for production of industrial products.
Evaluate simple downstream concepts for product recovery from fermentation processes.
Calculate economic metrics for bioprocesses, and devise a research/development plan for industrial implementation.

(1) Role of fermentation in the sustainable manufacture of industrial products (including cells, enzymes, proteins and chemicals). (2) Mass balances, gas-liquid mass transfer, heat transfer, elemental and redox balances as tools to assess bioprocesses. (3) Evaluation of productivity requirements of large-scale bioprocesses, including scale-up strategies. (4) Alternative feedstocks. (5) Two-stage fermentation, in situ product removal. (6) Downstream process concepts. (7) Economics, research and development planning.

27002/27022/27932, Kemi- , miljø- or Bioteknologifagpakke or bachelor or equivalent

Lectures, project and exercises