Single-Course English 5 ECTS

Industrial cell-based reaction engineering

Overall Course Objectives

The reactors used in the bio-industries are designed according to the same general principles as those elsewhere in the chemical industry. However, there are some specific characteristics of bio-reactions (fermentation) which require specialist treatment, such as the variable stoichiometry and complexities of scale-up. Using a quantitative approach, fermentations are analyzed with respect to feasibility and scale-up for the production of a range of bio-based products (including cells, proteins and chemicals). A variety of feedstocks (including waste sugars and gasses) as well as production technologies (including two-stage fermentation) will be discussed. Emphasis will be placed on bioprocess economics and industrial implementation.

Learning Objectives

  • Describe the role of fermentation in the context of bioprocesses for production of industrial products (including cells, proteins and chemicals).
  • Calculate mass balances for fermentations, including gas-liquid mass transfer
  • Calculate elemental and redox balances for fermentation processes
  • Evaluate the feasibility of fermentation processes in an industrial context and devise a research/development plan
  • Analyze the consistency of experimental data using simple models
  • Evaluate productivity requirements of large-scale fermentation
  • Calculate the heat of production of aerobic fermentation process
  • Describe the principles for design and scale-up of a bioreactor
  • Describe the role of two-stage fermentation and in-situ product removal in the context of bioprocesses for production of industrial products
  • Evaluate simple downstream concepts from fermentation processes
  • Evaluate simple economic models of bioprocesses.

Course Content

Role of fermentation in the sustainable manufacture of industrial products (including cells, proteins and chemicals). Stoichiometry of cellular reactions, redox balances, yield coefficients and black box models. Evaluation of the feasibility of fermentation, two-stage fermentation, and in-situ product removal in an industrial context. Heat balances. ATP balances and energetics. Scale-up and design of fermentation. Integration of protein engineering, metabolic engineering and process engineering for design. Gas-liquid mass transfer for gaseous and aerobic fermentation. Bioprocess economics.

Recommended prerequisites

27002/27022/27932, Kemi- , miljø- or Bioteknologifagpakke or bachelor or equivalent

Teaching Method

Lectures and exercises

Faculty

Remarks

Parallel course to 28345

See course in the course database.

Registration

Language

English

Duration

13 weeks

Institute

Chemical Engineering

Place

DTU Kalundborg Campus

Course code 28745
Course type Candidate
Semester start Week 35
Semester end Week 48
Price

7.500,00 DKK

Registration