Biosynthesis of natural products

• Understand and explain the nature of biosynthesis of polyketides.
• Understand and explain the nature of biosynthesis of ribosomal and non-ribosomal peptides.
• Understand and explain the nature of terpenoids and compounds of mixed biosynthetic origin.
• Predict the composition of the related gene cluster, in bacteria and fungi, based on structural analysis of a given natural product.
• Understand and be able to implement bioinformatic tools, such as antiSMASH, for analysis of secondary metabolite gene clusters,
• Understand the basic principles behinad the use of bioinformatics tools such as BLAST, HMMer, Interproscan for prediction of related enzyme activities.
• Understand and explain the nature of polyketide syntases and non-ribosomal peptide synthetases including their domain structures.
• Predict different types of natural products and their biosynthesis based on genome analysis.

Advanced understanding in biosynthesis of complex natural products, such as polyketides, bioactive ribosomal and non-ribosomal peptides, terpenoids and compounds of mixed biosynthetic origin. Use of bioinformatic tools such as antiSMASH, BLAST, and other tools for annotation of genes, gene clusters, and prediction of the nature of enzymes involved in the biosynthesis of natural products.
Importantly, this course is directed towards both biotech students, as well as students interested in organic chemistry, who want to strengthen their biochemical knowledge.

• 6 – 20 (Thurs 13-17)

26400

Lectures, exercises, literature search, group work and student presentations

Minimum: 10.

Please be aware that this course will only be held if the required minimum number of participants is met. You will be informed 8 days before the start of the course, whether the course will be held.