Course English 2.5 ECTS

Automation and control of yeast fermentation

Automation and Control of Yeast Fermentation

Want to gain an understanding of the theory and skills needed to make decisions related to on-line sensor selection in view of establishing closed-loop control on a model fermentation process (yeast)?

This course aims to provide participants with an understanding of the theory and skills needed to make decisions related to on-line sensor selection in view of establishing closed-loop control on a model fermentation process (yeast).

Participants will be introduced to the theory of process control, and will learn how to use model simulations to study the effect of applying control to a bioreactor. On-line sensor concepts will be introduced, and the participants will learn how to work with on-line data, first in terms of detecting outliers and replacing missing values, and then for classification.

For more details on scope, form and exam, please see course base

Learning outcomes

At the end of this course, participants will have an understanding of:

  • Implementation and simulation of a system of coupled differential equations on an aerobic yeast fermentation process
  • Standard and advanced sensors
  • How to apply control to a yeast fermentation process (in a simulation model)
  • Local sensitivity analysis
  • Missing value replacement and outlier detection in on-line data
  • Classification of datasets.

The course will be a mix of lectures, exercises in the lecture room and a homework assignment.

Who should attend?

The course is broadly applicable to anyone who is interested in learning about large-scale biomanufacturing operations and gaining hands-on experience in a simulated cGMP environment.

This course is perfect for:

  • New employees
  • Support personnel from Quality Control and Quality Assurance
  • Vendors and suppliers who provide equipment and services to the industry.

Prerequisites 

Some basic knowledge of MATLAB or Python is an advantage, but not a must.

Important information 

Here you will find important information for short course participants regarding cancellation policies, location and waitlist policies.

Fee, registration and location 

  1. This course is free for PhD students registered at a Danish university
  2. The course fee for PhDs registered at international institutions and faculty/staff employed by an academic institution is 7,000 DKK
  3. The course fee for industry participants is 10,000 DKK.

To register, please reach out to Program Coordinator, Seungmi Nam (seunam@dtu.dk). Send your name, university or company and department.

The application deadline is April 2023.

The course will take place in the pilot plant facilities at the Department of Chemical and Biochemical Engineering on DTU’s Lyngby campus.

The AIM-Bio project – funded by the Novo Nordisk Foundation

This course was developed in the framework of the AIM-Bio project (Accelerated Innovation in Manufacturing Biologics), in collaboration between DTU Bioengineering, DTU Chemical Engineering, and the Biomanufacturing Training and Education Center (BTEC) at North Carolina State University. The AIM-Bio project is funded by the Novo Nordisk Foundation.

Course instructor

Krist V. Gernaey

Professor

Krist V. Gernaey is a Professor in industrial fermentation technology (“The Novozymes professor”) at the Department of Chemical and Biochemical Engineering at DTU since January 2013. The focus of his work is the modeling, development and optimisation of industrial fermentation, biocatalysis, pharmaceutical and food production processes.

Central topics in his current work are the application and development of computer-aided tools for elucidation of (bio)process kinetics, uncertainty and sensitivity analysis methods, data-driven modelling and chemometrics (Process Analytical Technology – PAT), continuous production processes, process monitoring and control applied to bioprocesses, and investigation of mass transfer issues related to the characterisation and development of novel and existing processes and bioreactor types, ranging from microbioreactors to full-scale fermentors.

Registration

Duration

17-21 April 2023
Place

In-person on DTU Campus in Lyngby
ECTS

2.5

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Registration