Automation and control of yeast fermentation

Day 1

• Introduction of the model process (yeast, 2nd generation bioethanol process)
• Introduction to Matlab / Python
• Introduction of the mathematical model of the model process
• Local sensitivity analysis – ranking of model parameters
• Simulate modes of operation (hands on, exercise)
• Use of the model as a data generator (hands on, exercise)

Day 2

• Sensors – introduction (standard and advanced)
• Simulation of sensor behaviour – sensor models
• Introduction to process control

Day 3

• Common data flow in a process, from sensors to information
• Introduction to soft sensors
• Implementation/simulation of control strategies (example system, hands on)

Day 4

• Data handling – missing values
• Evaluation of sensor selection and its impact
• Data handling – missing values (hands on)

Day 5

• Classification of batch / fed-batch data
• Classification of batch / fed-batch data (hands on)
• Introduction to the assignment
• Questions / final evaluation

* The course schedule is subject to possible adjustments.

At the end of this course, participants will have an understanding of:

• Implementation and simulation of a system of coupled differential equations on an aerobic yeast fermentation process
• Standard and advanced sensors
• How to apply control to a yeast fermentation process (in a simulation model)
• Local sensitivity analysis
• Missing value replacement and outlier detection in on-line data
• Classification of datasets.

The course will be a mix of lectures, exercises in the lecture room and a homework assignment.

Some basic knowledge of MATLAB or Python is an advantage, but not a must.

Here you will find important information for short course participants regarding cancellation policies, location and waitlist policies.

1. This course is free for PhD students registered at a Danish university
2. The course fee for PhDs registered at international institutions and faculty/staff employed by an academic institution is 7,000 DKK
3. The course fee for industry participants is 15,000 DKK.

To register, please reach out to Program Coordinator, Seungmi Nam (seunam@dtu.dk). Send your name, university or company and department.

The application deadline is April 2024.

The course will take place in the pilot plant facilities at the Department of Chemical and Biochemical Engineering on DTU’s Lyngby campus.

This course was developed in the framework of the AIM-Bio project (Accelerated Innovation in Manufacturing Biologics), in collaboration between DTU Bioengineering, DTU Chemical Engineering, and the Biomanufacturing Training and Education Center (BTEC) at North Carolina State University. The AIM-Bio project is funded by the Novo Nordisk Foundation.