Course English 2.5 ECTS

Automation and control of yeast fermentation

Automation and Control of Yeast Fermentation

Want to gain an understanding of the theory and skills needed to make decisions related to on-line sensor selection in view of establishing closed-loop control on a model fermentation process (yeast)?

This course aims to provide participants with an understanding of the theory and skills needed to make decisions related to on-line sensor selection in view of establishing closed-loop control on a model fermentation process (yeast).

Participants will be introduced to the theory of process control, and will learn how to use model simulations to study the effect of applying control to a bioreactor. On-line sensor concepts will be introduced, and the participants will learn how to work with on-line data, first in terms of detecting outliers and replacing missing values, and then for classification.

For more details on scope, form and exam, please see course base

Course schedule

Day 1

  • Introduction of the model process (yeast, 2nd generation bioethanol process)
  • Introduction to Matlab / Python
  • Introduction of the mathematical model of the model process
  • Local sensitivity analysis – ranking of model parameters
  • Simulate modes of operation (hands on, exercise)
  • Use of the model as a data generator (hands on, exercise)

Day 2

  • Sensors – introduction (standard and advanced)
  • Simulation of sensor behaviour – sensor models
  • Introduction to process control

Day 3

  • Common data flow in a process, from sensors to information
  • Introduction to soft sensors
  • Implementation/simulation of control strategies (example system, hands on)

Day 4

  • Data handling – missing values
  • Evaluation of sensor selection and its impact
  • Data handling – missing values (hands on)

Day 5

  • Classification of batch / fed-batch data
  • Classification of batch / fed-batch data (hands on)
  • Introduction to the assignment
  • Questions / final evaluation

* The course schedule is subject to possible adjustments.

Learning outcomes

At the end of this course, participants will have an understanding of:

  • Implementation and simulation of a system of coupled differential equations on an aerobic yeast fermentation process
  • Standard and advanced sensors
  • How to apply control to a yeast fermentation process (in a simulation model)
  • Local sensitivity analysis
  • Missing value replacement and outlier detection in on-line data
  • Classification of datasets.

The course will be a mix of lectures, exercises in the lecture room and a homework assignment.

Who should attend?

The course is broadly applicable to anyone who is interested in learning about large-scale biomanufacturing operations and gaining hands-on experience in a simulated cGMP environment.

This course is perfect for:

  • New employees
  • Support personnel from Quality Control and Quality Assurance
  • Vendors and suppliers who provide equipment and services to the industry.


Some basic knowledge of MATLAB or Python is an advantage, but not a must.

Important information 

Here you will find important information for short course participants regarding cancellation policies, location and waitlist policies.

Fee, registration and location 

  1. This course is free for PhD students registered at a Danish university
  2. The course fee for PhDs registered at international institutions and faculty/staff employed by an academic institution is 7,000 DKK
  3. The course fee for industry participants is 15,000 DKK.

To register, please reach out to Program Coordinator,  Khaled Chatila ( Send your name, university or company and department.

The application deadline is April 2024.

The course will take place in the pilot plant facilities at the Department of Chemical and Biochemical Engineering on DTU’s Lyngby campus.

The AIM-Bio project – funded by the Novo Nordisk Foundation

This course was developed in the framework of the AIM-Bio project (Accelerated Innovation in Manufacturing Biologics), in collaboration between DTU Bioengineering, DTU Chemical Engineering, and the Biomanufacturing Training and Education Center (BTEC) at North Carolina State University. The AIM-Bio project is funded by the Novo Nordisk Foundation.

Course instructor



28th of April – 2nd of May 2025


DTU Lyngby Campus



Start 28 April 2025

15.000,00 DKK